What Is the Molecular Weight of MOTS-C?
The MOTS-C molecular weight is 2174.6 g/mol according to the current PubChem record for MOTS-c. PubChem also lists the molecular formula as C101H152N28O22S2 and the peptide sequence as MRWQEMGYIFYPRKLR.
For researchers working with synthetic peptide materials, molecular weight is an important reference point for understanding identity and interpreting analytical data.
Molecular weight can be used alongside:
- Peptide sequence
- Molecular formula
- Exact mass
- Monoisotopic mass
- HPLC data
- LC-MS results
- Certificate of Analysis (COA)
- Lot-specific analytical documentation
The distinction between these measurements is important. A nominal molecular weight provides a convenient chemical reference, while exact and monoisotopic mass values can be particularly useful when interpreting high-resolution mass-spectrometry data.
For MOTS-c, PubChem reports an exact mass of 2174.1110958 Da and a monoisotopic mass of 2173.1077409 Da in its chemical-properties section.
MOTS-C Molecular Weight at a Glance
| Property | MOTS-C Information |
|---|---|
| Common Name | MOTS-c |
| Peptide Length | 16 amino acids |
| Peptide Sequence | MRWQEMGYIFYPRKLR |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | 2174.6 g/mol |
| Exact Mass | 2174.1110958 Da |
| Monoisotopic Mass | 2173.1077409 Da |
| CAS | 1627580-64-6 |
| Classification | Mitochondrial-derived peptide |
PubChem identifies MOTS-c as a 16-amino-acid peptide and provides these chemical and sequence records.
MOTS-C Peptide Sequence
The human MOTS-c sequence is:
MRWQEMGYIFYPRKLR
This represents a 16-amino-acid peptide:
| Position | Amino Acid | Code |
|---|---|---|
| 1 | Methionine | M |
| 2 | Arginine | R |
| 3 | Tryptophan | W |
| 4 | Glutamine | Q |
| 5 | Glutamic acid | E |
| 6 | Methionine | M |
| 7 | Glycine | G |
| 8 | Tyrosine | Y |
| 9 | Isoleucine | I |
| 10 | Phenylalanine | F |
| 11 | Tyrosine | Y |
| 12 | Proline | P |
| 13 | Arginine | R |
| 14 | Lysine | K |
| 15 | Leucine | L |
| 16 | Arginine | R |
PubChem’s biologic description lists the sequence as MRWQEMGYIFYPRKLR.
Why the sequence matters
Molecular weight alone is not enough to identify a peptide.
Researchers can compare the expected sequence with:
- Molecular formula
- Calculated molecular mass
- Mass-spectrometry results
- Reference databases
- HPLC retention behavior
- Supplier specifications
- Batch-specific COA documentation
This makes MOTS-C peptide sequence an important supporting keyword for a molecular-weight-focused SEO page.
MOTS-C Molecular Formula
The molecular formula listed by PubChem is:
C101H152N28O22S2
This formula describes the elemental composition of the molecular form represented in the PubChem record.
The formula contains:
- Carbon
- Hydrogen
- Nitrogen
- Oxygen
- Sulfur
The presence of sulfur reflects the methionine residues in the peptide sequence.
Molecular formula vs. molecular weight
These terms are related but not identical.
Molecular formula describes the number of atoms of each element.
Molecular weight expresses the calculated mass of the molecular substance.
Exact mass uses the precise masses of the constituent isotopes.
Monoisotopic mass refers to the mass calculated using the principal naturally occurring isotope for each element.
These distinctions become especially relevant when researchers interpret high-resolution mass spectrometry.
MOTS-C Exact Mass and Monoisotopic Mass
For technical research, the exact and monoisotopic masses of MOTS-c can provide additional analytical reference points.
PubChem currently reports:
Molecular weight: 2174.6 g/mol
Exact mass: 2174.1110958 Da
Monoisotopic mass: 2173.1077409 Da
These values should not be treated as interchangeable.
A laboratory mass-spectrometry report may display observed ions rather than simply displaying the neutral molecular mass. Ionization, charge state, adducts, and instrument conditions can influence the observed mass-to-charge ratio.
Consequently, researchers interpreting an MS report should evaluate the m/z value, charge state, expected molecular mass, and analytical method together.
Why MOTS-C Molecular Weight Matters in Research
Molecular-weight information is particularly useful when researchers are evaluating peptide identity.
For a research peptide such as MOTS-c, a technical workflow might compare:
Expected sequence → calculated molecular characteristics → observed MS data → chromatographic profile → batch documentation
This creates multiple points of analytical reference.
A molecular-weight value by itself does not establish purity or identity. However, when combined with chromatographic and mass-spectrometric evidence, it can contribute to a broader analytical characterization.
MOTS-C and Mitochondrial-Derived Peptide Research
MOTS-c stands for mitochondrial open reading frame of the 12S rRNA-c.
Scientific literature describes MOTS-c as a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region.
The original 2015 study reported the discovery of MOTS-c and investigated its relationship with metabolic homeostasis in experimental models. The study described effects involving folate metabolism, purine biosynthesis, and AMPK signaling.
Later reviews have examined MOTS-c in the context of mitochondrial biology, metabolic signaling, cellular stress, and age-related research.
These publications provide scientific context for laboratory research involving MOTS-c, but experimental findings should not be interpreted as proof of a medical treatment effect.
MOTS-C 20mg and Molecular Weight
For a product described as MOTS-C 20mg, the “20mg” refers to the nominal quantity of research material, while 2174.6 g/mol refers to the molecular weight listed for MOTS-c by PubChem.
These are two completely different measurements.
20mg
A quantity of material.
2174.6 g/mol
The molecular weight of the listed MOTS-c molecular form.
Understanding this distinction is useful for researchers and helps avoid confusing product quantity with molecular characteristics.
A product page can therefore naturally target both:
- MOTS-C 20mg
- MOTS-C molecular weight
without treating the terms as interchangeable.
MOTS-C Molecular Weight and Mass Spectrometry
Mass spectrometry is one of the most useful analytical approaches for investigating peptide molecular identity.
A mass spectrometer measures ions according to their mass-to-charge ratio, commonly abbreviated as m/z.
For a peptide with an expected molecular mass around 2174.6 Da, researchers may observe different charged ions depending on the ionization conditions.
For example, a multiply charged peptide can produce an m/z value substantially lower than the molecular weight of the neutral molecule.
This means:
Molecular weight ≠ every m/z value displayed in an MS spectrum.
Researchers should therefore avoid interpreting a single spectral peak without considering:
- Charge state
- Expected molecular mass
- Adducts
- Ionization conditions
- Instrument resolution
- Calibration
- Sample preparation
For research-material characterization, MS results are strongest when accompanied by clear analytical documentation.
MOTS-C HPLC Analysis
High-performance liquid chromatography, or HPLC, can provide chromatographic information about a peptide sample.
For MOTS-C research material, an HPLC report may contain:
- Retention time
- Main peak
- Peak area
- Related peaks
- Detection conditions
- Sample identification
- Purity calculation
- Analytical method
HPLC and mass spectrometry provide different types of information.
HPLC
Primarily provides chromatographic separation and purity-related information.
Mass spectrometry
Provides molecular-mass information that can support identity characterization.
For this reason, a research peptide evaluated with both techniques may have a more informative analytical profile than one represented only by a headline purity number.
MOTS-C Purity and Molecular Weight
A common mistake in peptide research documentation is treating molecular weight and purity as the same type of measurement.
They are not.
Molecular weight describes the mass of the molecular entity.
Purity describes the proportion of the target material relative to detected components under a particular analytical method.
A MOTS-C sample could have the expected molecular weight while still containing other substances.
Conversely, an HPLC result may indicate a high chromatographic purity while molecular identity still needs to be confirmed independently.
For this reason, researchers should ideally review:
- Molecular identity
- Molecular mass
- HPLC purity
- Mass-spectrometry data
- COA
- Lot information
MOTS-C Certificate of Analysis
A Certificate of Analysis (COA) provides batch-specific analytical information.
A MOTS-C COA may include:
- Product name
- Lot number
- Testing date
- Testing laboratory
- HPLC purity
- Identity result
- Mass-spectrometry result
- Appearance
- Peptide content
- Analytical specification
- Test result
Why the lot number matters
The lot number connects the certificate to a particular batch.
Researchers should verify that the lot number on the COA corresponds to the material being evaluated.
A generic COA without a clear batch connection provides less useful evidence than a traceable, lot-specific certificate.
How to Evaluate a MOTS-C Molecular Weight Claim
When encountering a MOTS-C product page or research document, consider the following checklist.
Step 1: Confirm the Sequence
The listed human MOTS-c sequence should be consistent with MRWQEMGYIFYPRKLR.
Step 2: Confirm the Molecular Formula
PubChem lists C101H152N28O22S2 for its MOTS-c record.
Step 3: Compare the Molecular Weight
The listed molecular weight is 2174.6 g/mol.
Step 4: Review Exact Mass
PubChem reports an exact mass of 2174.1110958 Da.
Step 5: Review the Chemical Form
Different peptide forms, salts, counterions, or modifications can alter the mass that should be expected in analytical testing.
Step 6: Review MS Data
Compare the observed mass-to-charge values with the expected molecular characteristics.
Step 7: Review HPLC Data
Use chromatography as complementary evidence rather than treating it as a substitute for identity testing.
MOTS-C Molecular Weight vs. Exact Mass
The difference between molecular weight and exact mass is particularly useful for technical SEO because researchers frequently search for both terms.
| Measurement | MOTS-C |
|---|---|
| Molecular weight | 2174.6 g/mol |
| Exact mass | 2174.1110958 Da |
| Monoisotopic mass | 2173.1077409 Da |
The numbers should not be presented as competing answers.
They describe different calculated properties.
Molecular weight is generally the convenient value used for chemical reference.
Exact mass is calculated from precise atomic masses.
Monoisotopic mass uses the principal isotope of each constituent element.
This distinction becomes particularly relevant for high-resolution MS analysis.
MOTS-C Laboratory Research Applications
Scientific publications have investigated MOTS-c in several experimental contexts.
Research areas include:
- Mitochondrial signaling
- Metabolic biology
- Cellular stress
- Energy regulation
- Mitochondrial-derived peptides
- Skeletal-muscle research
- Cellular homeostasis
- Aging-related biology
The original research identified MOTS-c as a mitochondrial-derived 16-amino-acid peptide and investigated metabolic signaling in experimental systems.
Later reviews have discussed broader experimental interest in MOTS-c and mitochondrial-derived peptides.
For responsible SEO content, these should be described as research areas, rather than established clinical indications.
MOTS-C Molecular Weight: Common Research Questions
Researchers searching for MOTS-C molecular information may be trying to answer several different questions.
What is the molecular weight?
2174.6 g/mol according to PubChem.
What is the sequence?
MRWQEMGYIFYPRKLR.
What is the formula?
C101H152N28O22S2.
What is the exact mass?
2174.1110958 Da.
What is the monoisotopic mass?
2173.1077409 Da according to PubChem.
These technical details make the page useful for researchers looking for molecular-reference information rather than simply a product listing.
Research-Use Wording
MOTS-C research material is intended for laboratory research and scientific investigation only. It is not represented as an FDA-approved medication, dietary supplement, or therapeutic product. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition. This content does not provide human or veterinary dosing, administration, injection, or treatment instructions. Researchers should follow appropriate laboratory safety procedures, institutional protocols, supplier documentation, and all applicable laws and regulations.
Frequently Asked Questions About MOTS-C Molecular Weight
What is the molecular weight of MOTS-C?
PubChem lists the molecular weight of MOTS-c as 2174.6 g/mol for its listed molecular form.
What is the MOTS-C molecular formula?
The molecular formula listed by PubChem is C101H152N28O22S2.
What is the MOTS-C peptide sequence?
The human MOTS-c sequence is MRWQEMGYIFYPRKLR, consisting of 16 amino acids.
What is the exact mass of MOTS-C?
PubChem reports an exact mass of 2174.1110958 Da.
What is the monoisotopic mass of MOTS-C?
PubChem reports a monoisotopic mass of 2173.1077409 Da.
Why is MOTS-C molecular weight important?
Molecular weight provides a chemical reference that can be compared with sequence information and analytical measurements such as mass spectrometry.
Is MOTS-C molecular weight the same as its m/z value in mass spectrometry?
No. Mass spectrometry generally reports mass-to-charge ratio. A peptide can produce multiple charged ions, so observed m/z values can differ substantially from the neutral molecular weight.
Does molecular weight prove peptide purity?
No. Molecular weight supports molecular characterization but does not independently establish purity. HPLC, MS, and other analytical methods may provide complementary information.
What is MOTS-C HPLC testing?
HPLC is a chromatographic technique that can separate components of a peptide sample and provide purity-related analytical information.
What is a MOTS-C COA?
A Certificate of Analysis is a batch-specific document that can report analytical results such as purity, identity testing, lot number, testing date, and laboratory information.
Is MOTS-C a mitochondrial-derived peptide?
Yes. Scientific literature describes MOTS-c as a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region.
Is MOTS-C molecular weight the same for every chemical form?
Not necessarily. Researchers should verify the specific molecular form, including any salt or counterion, before comparing calculated and experimentally observed masses.